Eliquis is a commonly prescribed blood thinning medication that is used to reduce the risk of stroke and blood clots in patients with certain medical conditions. While Eliquis is generally considered safe and effective, there have been some concerns raised about its potential link to depression.

Eliquis and Depression: Is there a Connection?

Depression is a complex mental health condition that can be caused by a variety of factors, including genetics, life events, and certain medications. Some patients taking Eliquis have reported experiencing symptoms of depression, such as persistent sadness, loss of interest in activities, changes in appetite or sleep patterns, and feelings of worthlessness.

However, it is important to note that the relationship between Eliquis and depression is not well-established. The prescribing information for Eliquis does not list depression as a common side effect, and clinical trials have not found a significant association between Eliquis use and depression.

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Possible Explanations

There are several possible explanations for the reported cases of depression in patients taking Eliquis. It is possible that the symptoms of depression are unrelated to the medication and are instead caused by other factors, such as the underlying medical condition for which Eliquis is prescribed. Additionally, depression is a known side effect of certain medical conditions, and it is possible that the patients reporting depression symptoms were already predisposed to the condition.

Another possibility is that the reported cases of depression are a result of the psychological impact of taking a blood thinning medication. Some patients may experience anxiety or worry about the potential side effects or complications associated with blood thinners, which could contribute to feelings of depression.

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Talking to Your Doctor

If you are taking Eliquis and are experiencing symptoms of depression, it is important to talk to your doctor. They can evaluate your symptoms, review your medical history, and determine the best course of action. It may be necessary to adjust your medication or explore other treatment options for depression.


While there have been reports of depression in patients taking Eliquis, the evidence linking the medication to depression is limited. It is important to remember that every individual is unique, and what works for one person may not work for another. If you have concerns about the potential side effects of Eliquis or are experiencing symptoms of depression, it is important to consult with your healthcare provider.

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